Question 50

Sildenafil is contraindicated with nitroglycerin.

Sildenafil, a medication used to treat erectile dysfunction, can cause a significant drop in blood pressure when taken with nitroglycerin, leading to potentially life-threatening hypotension.

A) Amoxicillin

Amoxicillin is an antibiotic and does not interact with nitroglycerin. There are no known contraindications when these two medications are used together, making this option incorrect.

B) Sildenafil

Sildenafil is contraindicated with nitroglycerin due to the risk of severe hypotension. Both medications cause vasodilation, and their combined effects can dangerously lower blood pressure, making this option correct.

C) Levothyroxine

Levothyroxine is a thyroid hormone replacement and does not have any known interactions with nitroglycerin. Therefore, it does not pose a contraindication, rendering this option incorrect.

D) Metformin

Metformin is an oral medication used to manage type 2 diabetes and does not interact with nitroglycerin. There are no contraindications when these medications are taken together, making this option incorrect.

Conclusion

Sildenafil is definitively contraindicated with nitroglycerin due to the risk of severe hypotension, while the other options—amoxicillin, levothyroxine, and metformin—do not present any such risks. Understanding these interactions is crucial for safe medication management in patients requiring both types of medications.