Question 54

Sildenafil is contraindicated with nitroglycerin.

Sildenafil, a medication used to treat erectile dysfunction, should not be taken with nitroglycerin due to the risk of severe hypotension. Both medications cause vasodilation, which can lead to dangerously low blood pressure when used together.

A) Amoxicillin

Amoxicillin is an antibiotic that is not contraindicated with nitroglycerin. It works independently on bacterial infections and does not have any significant interaction with nitroglycerin, making it safe to use concurrently.

B) Sildenafil

Sildenafil is contraindicated with nitroglycerin because both medications can cause vasodilation, potentially leading to a significant drop in blood pressure. This combination can result in serious cardiovascular complications and should be avoided.

C) Levothyroxine

Levothyroxine is a thyroid hormone replacement and does not interact with nitroglycerin. Therefore, it does not pose any contraindication when used alongside nitroglycerin, making it a safe option in this context.

D) Metformin

Metformin is an oral hypoglycemic agent used to manage diabetes. There is no known interaction between metformin and nitroglycerin, so it can be taken safely without any contraindications.

Conclusion

Sildenafil is the only medication listed that poses a significant risk when taken with nitroglycerin due to the potential for severe hypotension. All other options, including amoxicillin, levothyroxine, and metformin, do not have contraindications with nitroglycerin, thus affirming sildenafil's unique risk profile in this scenario.